Baylor College of Medicine · PhysiologyCardiac Regeneration Research Unit
James F Martin · Houston, Texas
Research Focus
Dr. James F. Martin's lab at Baylor College of Medicine focuses on understanding how specific signaling pathways in the heart can promote cell proliferation and regeneration after injury. By investigating the Hippo-YAP and Wnt signaling pathways, the lab aims to develop innovative treatments for heart failure, a leading cause of death. The research uses advanced techniques in gene therapy and cell models to find ways to enhance the heart's ability to heal itself following conditions like myocardial infarction.
cardiac regenerationHippo-YAP signalingWnt signalingcardiomyocyte proliferationmyocardial infarction
Research Aims
3AIM 01Investigate the role of Hippo-YAP signaling in cardiac repair and regeneration.
AIM 02Explore the synergy between YAP and Wnt signaling in promoting cardiomyocyte proliferation.
AIM 03Develop gene therapy strategies targeting Hippo signaling to improve heart function after injury.
Skills the Lab Values
gene therapy techniquesinduced pluripotent stem cell (iPSC) culturePCRmouse modelsWestern blottingcell signaling assaysflow cytometryimmunofluorescence microscopyRNA sequencing
Output against the department
Publications457top 7% of dept.20th of 286
this lab
most publishedleast published
Citations30ktop 7% of dept.21st of 286
this lab
most citedleast cited
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