University of North Carolina at Chapel Hill · BiochemistryCook Quiescence Lab
Jeanette Gowen Cook · Chapel Hill, North Carolina
Research Focus
The lab led by Dr. Jeanette Gowen Cook at the University of North Carolina focuses on understanding the mechanisms that control cell division and how certain cancer cells can enter a dormant state called quiescence. This research is critical, as quiescent cancer cells often resist treatment, leading to cancer relapse. Using innovative biosensors, the lab aims to study the different states of cell quiescence and their impact on tumor behaviors. Ultimately, the team's work will contribute to improved cancer therapies and provide insights into how cells maintain their genetic integrity during division.
cell cyclequiescencecancer therapygenome maintenancebiosensorsDNA replicationsingle-cell analysiscell heterogeneity
Research Aims
4AIM 01Define intercellular heterogeneity in quiescent cancer cells
AIM 02Develop and validate biosensors for measuring quiescence depth
AIM 03Investigate the dynamics of DNA replication origin licensing
AIM 04Identify molecular controls that regulate cell cycle exit and quiescence
Skills the Lab Values
cell culturequiescence assessmentfluorescence microscopylive-cell imaginggeneticsbiochemistryfluorescence-activated cell sorting (FACS)transcriptomic analysisproteomic analysis
Output against the department
Publications151bottom 42% of dept.234th of 402
this lab
most publishedleast published
Citations5.3kbottom 31% of dept.276th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.