EUEmory University · Microbiology & Immunology
Shafer Lab
William Maurice Shafer · Atlanta, Georgia
Research Focus
Dr. William Maurice Shafer's lab at Emory University studies the genetics of Neisseria gonorrhoeae, the bacteria that causes gonorrhea. The research focuses on how these bacteria develop resistance to antibiotics through a structure called the MtrCDE efflux pump. By understanding the genetic factors that contribute to this resistance, the lab aims to inform future treatments and public health strategies against gonorrhea.
gonorrheaantibiotic resistanceMtrCDE efflux pumpNeisseria gonorrhoeaegeneticsvirulence factorstranscriptional controlantimicrobial peptidescry-electron microscopy
Research Aims
4AIM 01Investigate mutations in N. gonorrhoeae that affect antibiotic resistance.
AIM 02Determine the impact of these mutations on treatment efficacy in mouse models.
AIM 03Examine the relationship between MtrCDE efflux pump function and virulence factors.
AIM 04Explore genetic regulation of mtrCDE expression and its implications for resistance.
Skills the Lab Values
genetic manipulationPCRin vitro experimentsmouse modelscryo-electron microscopydrug binding assaysgene expression analysisantibiotic susceptibility testingmolecular cloning
Output against the department
Publications262top 21% of dept.103rd of 486
this lab
most publishedleast published
Citations12ktop 30% of dept.145th of 486
this lab
most citedleast cited
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