University of California-Davis · PhysiologyCalcium Channel Dynamics Lab
Jie Zheng · Davis, California
Research Focus
Dr. Jie Zheng's research lab at UC Davis focuses on understanding how specific ion channels in cells, known as calcium-activated nonselective cation channels (CAN channels), work to regulate important physiological functions. The lab investigates the molecular mechanisms behind the activation and inhibition of these channels, especially how mutations can lead to serious health conditions like cardiac disorders and skin diseases. By using both experimental and computational techniques, the team aims to uncover the rules that govern these channels and potentially develop new therapeutic strategies.
ion channelscalcium signalingTRPM4TRPM5human diseasesskin disorderscardiac functionchannel activationmultidisciplinary approach
Research Aims
5AIM 01Investigate the molecular mechanisms of TRPM4 and TRPM5 activation.
AIM 02Identify the role of calcium and membrane potential in channel regulation.
AIM 03Explore the impact of genetic mutations on ion channel function.
AIM 04Develop novel inhibitors for TRPM4 and TRPM5 channels.
AIM 05Utilize mouse models to understand the physiological effects of TRPM4 mutations.
Skills the Lab Values
patch clampcryo-electron microscopyCRISPR/Cas technologyfluorescence imagingmouse modelsmolecular modelingdata analysiscell cultureelectrophysiology
Output against the department
Publications260top 21% of dept.60th of 286
this lab
most publishedleast published
Citations23ktop 11% of dept.31st of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.