University of South Florida · PhysiologyYang Lymphatics Lab
Ying Yang · Tampa, Florida
Research Focus
Dr. Ying Yang's lab at the University of South Florida focuses on understanding Tuberous Sclerosis Complex (TSC), a chronic disease caused by mutations in TSC1 or TSC2 genes that lead to serious complications like fluid accumulation in the chest. The lab investigates the role of lymphatic vessels in TSC, particularly how the loss of TSC signaling affects lymphatic valve function and contributes to chylothorax. Through their research, they aim to identify new pathways and potential therapeutic targets for managing TSC.
Tuberous Sclerosis Complexlymphatic vasculaturechylothoraxTsc knockout micesignaling pathways
Research Aims
3AIM 01Determine pathological changes in the lymphatic vasculature following genetic deletion of Tsc genes.
AIM 02Identify the molecular mechanisms behind lymphatic valve loss due to Tsc mutations.
AIM 03Investigate approaches to reverse lymphatic valve loss in Tsc knockout models.
Skills the Lab Values
genetic knockout techniquesmouse modelshistologyimmunohistochemistrymolecular biology techniquesdata analysisPCRWestern blot microscopy
Output against the department
Publications361top 10% of dept.28th of 286
this lab
most publishedleast published
Citations6.7ktop 49% of dept.139th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.