UOHUniversity of Oklahoma-Health Sciences Center · Biology
Rajagopal Exosome Lab
Rajagopal Ramesh · Oklahoma City, Oklahoma
Research Focus
Dr. Rajagopal Ramesh's lab focuses on innovative cancer treatments using advanced drug delivery systems and immune modulation techniques. They explore how exosomes, small vesicles released by cells, can carry cancer medications directly to tumors to improve treatment effectiveness and reduce side effects. The lab's research also investigates ways to combine these treatments with immune checkpoint inhibitors to enhance the body’s immune response against lung cancer.
exosomescancer therapyimmune modulationdrug deliverylung cancernanoformulationimmune checkpoint inhibitorsanticancer drugstargeted therapy
Research Aims
3AIM 01Test exosomes as targeted drug carriers for lung cancer therapy.
AIM 02Evaluate the efficacy of exosome-loaded chemotherapeutics in vitro and in vivo.
AIM 03Investigate the impact of targeting HuR on immune checkpoint expression in lung cancer.
Skills the Lab Values
cell cultureexosome isolationdrug loading and release studiesin vitro cytotoxicity assaysin vivo tumor modelsmagnetic resonance imaging (MRI)nanoparticle formulationimmunohistochemistrymolecular biology techniques
Output against the department
Publications229top 27% of dept.279th of 1,033
this lab
most publishedleast published
Citations15ktop 25% of dept.257th of 1,033
this lab
most citedleast cited
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