Duke University · ChemistryHong Oncology Lab
Jiyong Hong · Durham, North Carolina
Research Focus
Dr. Jiyong Hong's lab focuses on developing innovative cancer therapies that target specific DNA repair mechanisms in prostate cancer cells. They are investigating how to inhibit the Rev1 protein, which plays a crucial role in DNA damage tolerance, to make cancer cells more sensitive to treatments and improve patient outcomes. The lab's research aims to provide new strategies for overcoming drug resistance in metastatic castration-resistant prostate cancer (mCRPC), a particularly aggressive form of prostate cancer.
prostate cancerDNA repairtranslesion DNA synthesisRev1drug resistancecancer therapyBRCA mutationsinhibitorsmCRPC
Research Aims
5AIM 01Investigate the role of Rev1 in DNA damage tolerance mechanisms in prostate cancer cells.
AIM 02Characterize small molecule inhibitors that disrupt Rev1 function in vitro.
AIM 03Test the effectiveness of Rev1 inhibitors in murine xenograft models of prostate cancer.
AIM 04Analyze the impact of Rev1 inhibition on cancer cell sensitivity to DNA-damaging agents.
AIM 05Evaluate the safety and pharmacological properties of JH-RE-06 and its derivatives in mCRPC models.
Skills the Lab Values
cell culturemouse modelsdrug screeningmolecular cloningbiochemical assaysflow cytometryWestern blotstructural biology techniquespharmacologyin vivo tumor modeling
Output against the department
Publications140bottom 33% of dept.143rd of 216
this lab
most publishedleast published
Citations4.5kbottom 34% of dept.142nd of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.