Loyola University Chicago · PhysiologyCalcium Regulation and Heart Health Lab
Seth L Robia · Chicago, Illinois
Research Focus
Dr. Seth Robia's research lab at Loyola University Chicago focuses on the regulation of calcium transport in heart cells. The lab studies how small proteins called micropeptides influence the function of calcium pumps in the heart, leading to better understanding of heart problems such as heart failure. Through various experimental techniques, they investigate the mechanisms by which proteins interact and how these interactions change in health and disease.
calcium transportSERCA pumpmicropeptidesheart failureprotein interactions
Research Aims
5AIM 01Investigate how micropeptides regulate the SERCA calcium pump activity.
AIM 02Identify structural features of micropeptides that influence their regulatory effects.
AIM 03Understand the relationship between calcium pump regulation and heart disease.
AIM 04Explore alternative binding modes of regulatory proteins on SERCA.
AIM 05Examine the impact of genetic variants on calcium transport health.
Skills the Lab Values
NMR spectroscopyfluorescence methodsmass spectrometrycell culturebiochemical assays
Output against the department
Publications195top 34% of dept.98th of 286
this lab
most publishedleast published
Citations2.3kbottom 15% of dept.243rd of 286
this lab
most citedleast cited
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