University of Southern California · PhysiologyAlpha-Synuclein Dynamics Lab
Ansgar B Siemer · Los Angeles, California
Research Focus
Dr. Ansgar Siemer's lab focuses on the role of intrinsically disordered regions in alpha-synuclein fibrils, proteins linked to neurodegenerative diseases like Lewy body dementia and Alzheimer's. By studying how these disordered regions interact with other cellular components, the lab aims to improve our understanding of the underlying mechanisms of toxicity and develop potential biomarkers and therapies for these conditions.
alpha-synucleinintrinsically disordered regionsamyloid fibrilsLewy body dementianeurodegenerative diseasestoxic proteinsmolecular dynamicsbiomarkerstherapeuticsdisease modeling
Research Aims
3AIM 01Determine how intrinsic disordered regions change during fibril formation
AIM 02Investigate the effect of fibril polymorphs on disordered region dynamics
AIM 03Explore the interaction between alpha-synuclein fibrils and binding partners like DNAJB1
Skills the Lab Values
solid-state NMRcryo-electron microscopymolecular dynamics simulationsprotein modelingcell culturebiochemical assayscytotoxicity assessmentsdata analysis with Pythonmolecular interaction studiesstructural biology techniques
Output against the department
Publications53bottom 8% of dept.264th of 286
this lab
most publishedleast published
Citations4.2kbottom 35% of dept.185th of 286
this lab
most citedleast cited
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