New York University · BiologyThe Leukemia Nexus
Iannis Aifantis · New York, New York
Research Focus
Iannis Aifantis' lab at NYU focuses on understanding the mechanisms of acute myeloid leukemia (AML) and other blood cancers. The research explores how RNA-binding proteins affect cell differentiation and how inflammation impacts the immune response in leukemia. By using advanced techniques like CRISPR, the lab aims to identify new therapeutic targets and improve treatment outcomes for leukemia patients.
acute myeloid leukemiaRNA binding proteinsCRISPRepigeneticsinflammationleukemiahematopoiesis3D chromatin architecturetumor microenvironmentdifferentiation therapy
Research Aims
5AIM 01Investigate the role of ZFP36L2 in AML cell differentiation and growth.
AIM 02Map and characterize 3D regulatory elements in leukemia.
AIM 03Explore the impact of inflammation on immune response in AML.
AIM 04Identify mRNA targets modulated by RNA binding proteins in AML.
AIM 05Assess how 3D chromatin architecture alters during leukemogenesis.
Skills the Lab Values
CRISPR/Cas9RNA sequencingcell cultureWestern blotepigenomic profilingHiChIP analysisflow cytometrymouse modelsgenetic screeningin vivo studies
Output against the department
Publications449top 10% of dept.99th of 1,033
this lab
most publishedleast published
Citations27ktop 13% of dept.137th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.