Boston University · BiologyAlzheimer's MicroRNA Research Lab
Jean-Pierre Roussarie · Boston, Massachusetts
Research Focus
The Roussarie lab at Boston University Medical Campus focuses on understanding how specific genes and microRNAs influence vulnerability to Alzheimer's disease. Their research investigates the role of miR-129-2, a microRNA that may help protect neurons in the entorhinal cortex from neurodegeneration related to Alzheimer's. By mapping its expression patterns and studying its effects on tau accumulation, the lab aims to identify potential therapeutic targets to mitigate early stages of Alzheimer's disease.
Alzheimer's DiseasemicroRNAtau pathologyneurodegenerationgene regulationentorhinal cortexneuronal vulnerabilitytherapeutic targetsRNA sequencing
Research Aims
3AIM 01Map the expression of miR-129-2 in entorhinal cortex across different species and disease stages.
AIM 02Investigate how miR-129-2 interacts with other genes to regulate Alzheimer-related pathology.
AIM 03Test the potential of miR-129-2 as a therapeutic target to reduce tau accumulation in neurons.
Skills the Lab Values
single-nucleus RNA sequencingin situ hybridizationmouse modelsgene expression analysiscell culturedata analysismolecular cloningimmunohistochemistrybioinformatics
Output against the department
Publications27bottom 3% of dept.1,002nd of 1,033
this lab
most publishedleast published
Citations526bottom 2% of dept.1,011th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.