University of Nevada-Reno · PharmacologyThe Adhesion Dynamics Lab
Lai Wen · Reno, Nevada
Research Focus
Dr. Lai Wen's lab focuses on understanding how certain proteins regulate the adhesion of immune cells, specifically neutrophils, to blood vessel walls during inflammation. This research is crucial for tackling cardiovascular diseases, as inflammation plays a major role in heart-related issues. By exploring the interactions between proteins like kindlin-3 and talin-1, the lab aims to uncover new mechanisms that could lead to innovative therapies to reduce tissue damage during inflammatory responses.
neutrophil adhesionintegrin activationinflammationischemia-reperfusion injurycardiovascular disease
Research Aims
3AIM 01Investigate how kindlin-3 promotes integrin activation in neutrophils.
AIM 02Determine the role of talin-1 in neutrophil adhesion via integrin activation.
AIM 03Assess the effects of blocking kindlin-3 on ischemia-reperfusion injury.
Skills the Lab Values
animal modelsflow cytometrycell culturelive cell imagingmolecular cloning
Output against the department
Publications44bottom 5% of dept.438th of 462
this lab
most publishedleast published
Citations914bottom 3% of dept.447th of 462
this lab
most citedleast cited
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