University of California-Santa Cruz · EngineeringBenedict Genomics Lab
Benedict Paten · Santa Cruz, California
Research Focus
The lab led by Benedict Paten at UC Santa Cruz focuses on advancing genomics, particularly in understanding cancer and vertebrate evolution. They develop innovative methods for accurately detecting genetic variants in cancer genomes and create tools for comparing thousands of vertebrate genomes. Their research aims to improve diagnostic strategies and enhance our understanding of complex genetic regions associated with various diseases.
cancer genomicspangenomegenome alignmentsomatic variantscomparative genomicstelomere-to-telomere sequencingmachine learningstructural variantsgenetic disorders
Research Aims
3AIM 01Create comprehensive benchmark variant sets for tumor-normal cell lines.
AIM 02Reduce reference bias in variant calling using pangenome information.
AIM 03Develop scalable methods for aligning thousands of vertebrate genomes.
Skills the Lab Values
genome sequencingpangenome analysisstructural variant detectionbioinformaticsdata visualizationhigh-throughput sequencingmachine learning applicationsgenome assemblysoftware development
Output against the department
Publications354top 22% of dept.60th of 278
this lab
most publishedleast published
Citations52ktop 5% of dept.14th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.