University of Pennsylvania · NeuroscienceDas Neurodegeneration Lab
Sandhitsu Das · Philadelphia, Pennsylvania
Research Focus
Dr. Sandhitsu Das's lab at the University of Pennsylvania focuses on understanding the relationship between tau pathology and neurodegeneration in Alzheimer's disease through advanced imaging techniques. The lab investigates how variations in tau levels can affect brain structure and cognitive function, aiming to identify different patient phenotypes that may influence disease progression. This research could improve clinical management and drug development for Alzheimer's disease by providing insights into individual vulnerabilities and resiliencies.
Alzheimer's Diseasetau pathologyneurodegenerationmultimodal imagingphenotype discoverycognitive declinebrain structureimaging analysis
Research Aims
5AIM 01Explore the relationship between tau pathology and neurodegeneration in Alzheimer's disease
AIM 02Identify variability in the tau-neurodegeneration relationship
AIM 03Develop a mismatch metric for categorizing patient phenotypes
AIM 04Evaluate the predictive value of the mismatch metric for cognitive decline
AIM 05Assess the impact of co-pathologies on neurodegeneration patterns.
Skills the Lab Values
magnetic resonance imaging (MRI)positron-emission tomography (PET)digital histopathologydata-driven clusteringlinear regression modelingneuroanatomy assessmentstatistical analysiscognitive assessment techniques
Output against the department
Publications413top 15% of dept.100th of 671
this lab
most publishedleast published
Citations11ktop 36% of dept.239th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.