Purdue University-Main Campus · ChemistrySchlebach Lab
Jonathan Patrick Schlebach · West Lafayette, Indiana
Research Focus
Dr. Jonathan Patrick Schlebach's lab at Purdue University focuses on understanding how certain proteins, specifically membrane proteins, get misfolded and how this can lead to diseases like cystic fibrosis. They use cutting-edge techniques to explore how the production, quality control, and mutations of these proteins affect cellular health. This research aims to develop better therapies for patients with genetic variants of cystic fibrosis by optimizing treatment strategies.
membrane proteinsprotein misfoldingcystic fibrosisproteostasisdrug discovery
Research Aims
5AIM 01Identify specific conformational defects in membrane proteins that promote misfolding.
AIM 02Develop innovative techniques for drug combinations targeting rare cystic fibrosis variants.
AIM 03Explore the relationship between membrane protein topology and quality control.
AIM 04Characterize the interactions between membrane proteins and molecular chaperones in the endoplasmic reticulum.
AIM 05Utilize machine learning to classify the pharmacological properties of cystic fibrosis variants.
Skills the Lab Values
CRISPR/Cas9deep mutational scanningcell cultureprotein expressionbiochemical profiling
Output against the department
Publications80bottom 17% of dept.180th of 216
this lab
most publishedleast published
Citations1.3kbottom 10% of dept.195th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.