Northwestern University · BiologyT Cell Dynamics Lab
Weiguo Cui · Evanston, Illinois
Research Focus
Dr. Weiguo Cui's lab at Northwestern University focuses on understanding how T cells respond to chronic viral infections. They investigate the mechanisms behind T cell exhaustion and differentiation, aiming to harness this knowledge to develop new therapeutic strategies. By exploring how specific T cell subsets are formed and function, the lab aims to improve treatments for conditions like HIV and cancer.
T cell exhaustionchronic viral infectioneffector T cellsTCR signalingimmunotherapysingle cell RNA sequencingdendritic cellsCRISPRcell differentiationimmune response
Research Aims
3AIM 01Investigate how TCR signaling strength affects the differentiation of T cell subsets in chronic viral infection.
AIM 02Identify the mechanisms by which CD4+ T helper cells license dendritic cells for CD8+ T cell activation.
AIM 03Use targeted CRISPR screening to manipulate TCR signaling and promote effector T cell formation to combat exhaustion.
Skills the Lab Values
single-cell RNA sequencingT cell receptor sequencingCRISPR gene editinggenetic model developmentflow cytometrycell culture techniqueshigh-throughput screeningcomputational biologydata analysisimmunological assays
Output against the department
Publications187top 34% of dept.355th of 1,033
this lab
most publishedleast published
Citations12ktop 32% of dept.328th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.