University of California-Los Angeles · ChemistryTelomerase Structure and Function Lab
Juli Feigon · Los Angeles, California
Research Focus
Dr. Juli Feigon's lab at UCLA studies the structure and function of telomerase, the enzyme responsible for maintaining telomeres, which are the protective ends of chromosomes. By combining advanced techniques like cryo-electron microscopy and NMR spectroscopy, the lab aims to understand how telomerase works, how it is regulated, and how mutations can lead to diseases like dyskeratosis congenita and aplastic anemia. This research is significant for revealing insights into aging, stem cell function, and potential therapeutic targets for various diseases.
telomerasetelomeresstructural biologybiochemistrycryoelectron microscopyNMR spectroscopyagingdisease mechanismsDNA replication
Research Aims
4AIM 01Investigate the molecular mechanism of telomerase assembly and function.
AIM 02Explore how telomere binding proteins regulate telomere synthesis.
AIM 03Analyze the structural differences and similarities between human and Tetrahymena telomerase.
AIM 04Visualize the in situ dynamics of telomerase at telomeres using cryoET.
Skills the Lab Values
Cryo-electron microscopy (cryoEM)NMR spectroscopyBiochemical assaysMolecular cloningCell culture techniquesProtein purificationDNA manipulationStructural modelingFluorescence microscopy
Output against the department
Publications278top 41% of dept.87th of 216
this lab
most publishedleast published
Citations15ktop 33% of dept.71st of 216
this lab
most citedleast cited
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