University of Virginia-Main Campus · GeneticsBone Health and Regeneration Lab
Charles R Farber · Charlottesville, Virginia
Research Focus
Dr. Charles R. Farber's lab at the University of Virginia focuses on understanding the genetic factors that influence bone health and repair. By using mouse models, they are exploring how different genes affect bone regeneration and strength, which could lead to new treatments for conditions like osteoporosis. This research is particularly significant because bone repair is a major public health issue, with millions suffering from fractures and impaired healing each year.
bone regenerationgenetic analysisbone strengthmouse modelsosteoporosisgenome-wide association studiesintramembranous bone healingtranscriptomicstherapeutic targetspublic health
Research Aims
3AIM 01Identify genes influencing intramembranous bone regeneration using systems genetics in mice.
AIM 02Conduct genome-wide association studies for bone strength and related traits in a large mouse population.
AIM 03Validate the function of candidate genes in bone healing processes.
Skills the Lab Values
genome-wide association studies (GWAS)transcriptomic analysissingle cell RNA sequencingmouse handling and caremolecular biology techniquesin vitro experimentsdata analysis with Bayesian networksgenetic mappingexperimental designcell culture
Output against the department
Publications205top 41% of dept.105th of 259
this lab
most publishedleast published
Citations13ktop 42% of dept.108th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.