Yale University · NeuroscienceSynaptic Mechanisms Lab
Shyam S Krishnakumar · New Haven, Connecticut
Research Focus
Dr. Shyam S Krishnakumar's lab focuses on understanding the complex mechanisms of synaptic transmission, particularly the roles of proteins like Complexin and Synaptotagmin in neurotransmitter release. They use a variety of experimental approaches, including studies in model organisms such as worms and mice, to explore how these proteins interact and regulate synapse function. Their research may provide insights into neurological disorders by enhancing our understanding of synaptic exocytosis.
synaptic transmissionComplexinSynaptotagminneurotransmitter releaseC. elegansmouse modelsCRISPRprotein interactioncomputational modeling
Research Aims
5AIM 01Compare the functions of Complexin across different species
AIM 02Investigate the interactions between Complexin and Synaptotagmin
AIM 03Analyze the effects of genetic variants on synaptic function
AIM 04Develop mechanistic models of synaptic transmission
AIM 05Utilize advanced imaging techniques to study neurotransmitter release.
Skills the Lab Values
molecular biology techniquesCRISPR/Cas9 gene editingcell cultureimmunocytochemistrysingle-vesicle docking assaysfluorescent imagingphysiological assayscomputational modelingmodel organism studies
Output against the department
Publications100bottom 34% of dept.444th of 671
this lab
most publishedleast published
Citations2.5kbottom 16% of dept.562nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.