University of Pennsylvania · BiologyThe Lung Regeneration Lab
Andrew Vaughan · Philadelphia, Pennsylvania
Research Focus
Dr. Andrew Vaughan's research lab focuses on understanding how the lungs repair themselves after injury from respiratory viruses like influenza and SARS-CoV-2. They investigate the regeneration of both the epithelial and endothelial layers of lung tissue, aiming to uncover the molecular pathways that support recovery and prevent severe complications such as acute respiratory distress syndrome (ARDS). The lab's work is crucial for developing therapies to improve lung function and reduce mortality rates associated with viral pneumonia.
lung regenerationendothelial cellsepithelial cellsviral pneumoniaacute respiratory distress syndromeangiocrine factorsTGF-betaSPARCL1molecular pathwayspublic health
Research Aims
5AIM 01Define how TGF-beta promotes lung vascular repair.
AIM 02Investigate the role of SPARCL1 in alveolar epithelial regeneration.
AIM 03Explore the influence of endothelial cells on epithelial repair.
AIM 04Identify molecular mechanisms of capillary endothelial regeneration.
AIM 05Develop targeted therapies for lung vascular repair.
Skills the Lab Values
cell culturemolecular biology techniquesanimal modelsChIP-seqdata modelingsignal transduction assaysprotein assaystissue regeneration studiesgene expression analysisfluorescent microscopy
Output against the department
Publications256top 23% of dept.241st of 1,033
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.565th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.