Iowa State University · Microbiology & ImmunologyArchaeal Biology and Evolution Lab
Stephen David Bell · Ames, Iowa
Research Focus
Dr. Stephen David Bell's lab focuses on studying archaeal microorganisms to better understand fundamental biological processes that are also present in more complex eukaryotic cells. By investigating how archaea organize their DNA and manage gene expression, the lab aims to uncover parallels to eukaryotic systems, offering insights into evolution and essential molecular functions. Their work has significant implications for understanding the basic mechanisms of life.
archaeaDNA replicationgene expressionchromosome architectureSulfolobusepigeneticsmolecular biologyevolutiongenome organization
Research Aims
4AIM 01Investigate the molecular biology of archaea to uncover insights into the evolution of eukaryotic systems.
AIM 02Explore the role of the SMC superfamily protein ClsN in DNA organization and gene expression.
AIM 03Integrate chromosome architecture studies with DNA replication research for a comprehensive understanding of genome dynamics.
AIM 04Examine the mechanistic basis of epigenetic states in Sulfolobus and their potential inheritance across generations.
Skills the Lab Values
DNA replication techniquesgene transcription assaysin vitro experimentationsingle-molecule approachesin vivo studiesprotein purificationcell culturegenomic analysisbioinformatics