Washington University in St Louis · NeuroscienceAlzheimer's Disease Mechanisms Lab
Joanna L Jankowsky · Saint Louis, Missouri
Research Focus
Dr. Joanna Jankowsky's lab at Washington University focuses on understanding the diverse biological mechanisms that contribute to the development and progression of Alzheimer's disease. By using specialized mouse models that express amyloid precursor protein in different types of neurons, the lab investigates how these variations influence amyloid plaque formation and the subsequent effects on cognitive function. The goal is to uncover the relationship between neuron behavior and Alzheimer's disease pathology, which may lead to improved therapeutic strategies.
Alzheimer's diseaseamyloid pathologyneuronal heterogeneitytransgenic modelscognitive function
Research Aims
3AIM 01Characterize the differences in amyloid plaques produced by GABAergic and glutamatergic neurons.
AIM 02Investigate how neuronal subtype differences influence APP processing using transcriptomic analysis.
AIM 03Evaluate the impact of distinct amyloid aggregate structures on cognitive function and cell behavior.
Skills the Lab Values
mouse modelselectron microscopysingle-nucleus RNA sequencing (snRNAseq)mass spectrometrycognitive testinghistological stainingdata analysis in neurosciencemolecular biology techniquesin vivo seeding assaysgenetic manipulation
Output against the department
Publications89bottom 28% of dept.481st of 671
this lab
most publishedleast published
Citations9.2ktop 43% of dept.287th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.