University of North Carolina at Chapel Hill · PharmacologyThe Psychedelic Receptor Lab
Bryan L. Roth · Chapel Hill, North Carolina
Research Focus
Dr. Bryan L. Roth's lab focuses on understanding how psychoactive drugs, like LSD, interact with specific receptors in the brain that are crucial for treating mental disorders. They use advanced techniques to study the structures of serotonin and Mas-related receptors to uncover how these drugs work at a molecular level. This research aims to improve drug design for conditions such as schizophrenia and chronic pain, leading to safer and more effective treatments.
psychoactive drugsserotonin receptorsLSDchronic painMRGPR receptorsdrug designmental disordersG protein-coupled receptorsbiased signalingtranscriptional changes
Research Aims
5AIM 01Investigate the molecular mechanisms of LSD and other psychedelics at serotonin receptors.
AIM 02Determine the structural details of MRG-family receptors related to pain and drug effects.
AIM 03Develop chemical tools to modulate receptor functions for therapeutic application.
AIM 04Study differences between human and rodent receptor interactions with drugs.
AIM 05Explore the transcriptional changes induced by psychedelic drug actions in neurons.
Skills the Lab Values
structural biologymolecular modelingsite-directed mutagenesiscryoelectron microscopycell culturefunctional assayshigh-throughput screeningdocking studiesligand-receptor interaction analysisgene expression analysis
Output against the department
Publications957top 2% of dept.10th of 462
this lab
most publishedleast published
Citations83ktop 2% of dept.7th of 462
this lab
most citedleast cited
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