University of Michigan-Ann Arbor · BiologyCenter for Keratinocyte Immunology
Pierre Coulombe · Ann Arbor, Michigan
Research Focus
Dr. Pierre Coulombe's lab at the University of Michigan studies how skin cells called keratinocytes influence the immune response during skin inflammation. Their research focuses on understanding how signals produced by these cells can affect immune cells like neutrophils, which play a critical role in skin disorders such as psoriasis and atopic dermatitis. By exploring how different proteins in keratinocytes interact with immune pathways, the lab aims to uncover new ways to diagnose and treat chronic skin diseases.
innate immunityskin inflammationkeratinocyte signalingneutrophil infiltrationchronic skin diseasesbiomarkersimmune responsestress responsepsoriasisatopic dermatitis
Research Aims
3AIM 01Compare immune cell infiltration patterns in mice lacking keratin 16 or 17 after skin stress exposure.
AIM 02Identify the specific cellular mechanisms by which keratin 16 and 17 regulate immune responses in keratinocytes.
AIM 03Investigate the role of macrophages in mediating neutrophil responses in stressed skin.
Skills the Lab Values
cell culturemouse modelsimmunohistochemistryflow cytometryRNA sequencingWestern blotCRISPRsignal transduction assaysgene knockout techniquesbiochemical assays
Output against the department
Publications331top 16% of dept.162nd of 1,033
this lab
most publishedleast published
Citations18ktop 22% of dept.224th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.