Thomas Jefferson University · BiochemistryAlnemri Lab
Emad S Alnemri · Philadelphia, Pennsylvania
Research Focus
Dr. Emad S Alnemri's lab at Thomas Jefferson University focuses on understanding the NLRP3 inflammasome, a key player in the body's inflammatory response. They investigate how this complex is activated in response to infections and tissue damage, which may lead to various inflammatory diseases such as arthritis and type 2 diabetes. By studying the molecular mechanisms behind NLRP3 activation, they aim to discover new therapeutic approaches to manage these conditions.
inflammasomeNLRP3caspase-1inflammatory diseasespost-translational modification
Research Aims
5AIM 01Elucidate the mechanisms of NLRP3 inflammasome activation.
AIM 02Investigate post-translational modifications of NLRP3 induced by Toll-like receptors.
AIM 03Identify the role of kinases in the activation of the NLRP3 inflammasome.
AIM 04Explore the impact of NLRP3 activation on inflammatory responses in vivo.
AIM 05Develop therapeutic strategies targeting the NLRP3 inflammasome.
Skills the Lab Values
Western blotmass spectrometrycell cultureanimal modelsphosphorylation analysis
Output against the department
Publications226top 35% of dept.138th of 402
this lab
most publishedleast published
Citations71ktop 3% of dept.12th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.