WMCWeill Medical College of Cornell University · Pharmacology
NAD+ Dynamics Lab
Yue Yang · New York, New York
Research Focus
Dr. Yue Yang's lab focuses on understanding how obesity affects pancreatic beta cells, which are essential for insulin production. They investigate the role of NAD+, a metabolite that supports cell function and survival, and how its depletion contributes to diabetes. By exploring new compounds that boost NAD+ levels, they aim to develop innovative therapies to treat Type 2 Diabetes and restore beta cell function.
NAD+ metabolismobesityType 2 Diabetesbeta cell dysfunctioninsulin secretion
Research Aims
3AIM 01Uncover the mechanisms of NAD depletion in beta cells due to obesity.
AIM 02Identify metabolic pathways influenced by NAD boosters to restore beta cell function.
AIM 03Investigate the relationship between beta cell NAD content and functional decline in Type 2 Diabetes.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysRNA extractionPCRflow cytometry
Output against the department
Publications300top 26% of dept.121st of 462
this lab
most publishedleast published
Citations11ktop 34% of dept.159th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.