Pennsylvania State University-Main Campus · BiochemistryThe Genomic Resilience Lab
George Lucian Moldovan · University Park, Pennsylvania
Research Focus
Dr. George Lucian Moldovan's lab studies how cells manage DNA damage during replication. They focus on understanding the mechanisms that prevent and repair damage to DNA, which is crucial for maintaining genomic stability and preventing diseases like cancer. By exploring the roles of specific proteins in repairing DNA, the lab aims to uncover insights that could improve cancer therapies and enhance our understanding of how cells respond to DNA damage.
DNA damage repaircellular homeostasisgenomic stabilityDNA replicationcancer therapyAPOPTOSISBRCA mutationschemoresistancenuclease processingsingle-stranded DNA
Research Aims
3AIM 01Investigate how CAF1 regulates PRIMPOL-mediated DNA fork restart.
AIM 02Examine the role of PARP10 in suppressing single-stranded DNA gaps.
AIM 03Explore how ssDNA gaps are processed into cytotoxic structures.
Skills the Lab Values
cell culturebiochemical assaysimaging techniquesmolecular cloningCRISPRDNA extractionPCRprotein purificationgenetic manipulationWestern blot
Output against the department
Publications126bottom 36% of dept.257th of 402
this lab
most publishedleast published
Citations8.8kbottom 46% of dept.218th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.