UMCUniversity of Massachusetts Chan Medical School · Biology
Inflammation and Immune Response Laboratory
Jiann-Jyh Lai · Worcester, Massachusetts
Research Focus
Dr. Jiann-Jyh Lai's lab at the University of Massachusetts Medical School focuses on understanding how the immune system detects cell injury and initiates inflammatory responses. Their research specifically investigates novel receptors and ligands that are involved in this process, which can impact various diseases. By using both human and mouse models, the lab aims to uncover new mechanisms that could lead to innovative treatments for conditions like stroke, heart attacks, and cancer.
DAMP receptorsinnate immunitysterile inflammationGAPDHimmune responsedisease pathologycell injurysignal transductionhumanized mousetherapeutic targets
Research Aims
3AIM 01Identify the innate immune cells that respond to GAPDH in humans and the role of Clec17a in this process.
AIM 02Characterize the murine counterpart of human Clec17a and its role in immune response.
AIM 03Determine the molecular mechanisms behind the activation of innate immune cells by Clec17a and CD209f/g.
Skills the Lab Values
immunology techniquescell cultureflow cytometrymolecular cloningWestern blotRT-PCRanimal handlinggenetic manipulationprotein expressionin vivo assays
Output against the department
Publications17bottom 2% of dept.1,012th of 1,033
this lab
most publishedleast published
Citations2.0kbottom 13% of dept.897th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.