Stanford University · NeuroscienceAlzheimer's Genetics and Therapeutics Lab
Michael D Greicius · Stanford, California
Research Focus
Dr. Michael D. Greicius's lab at Stanford University focuses on Alzheimer's disease, particularly the genetic factors that influence risk for the disease. Using advanced techniques like long-read sequencing, the lab explores how variations in the APOE gene and other relevant genes affect Alzheimer's risk in individuals of different ancestries. The ultimate goal is to identify new therapeutic targets that may lead to better treatments for this devastating disease.
Alzheimer's DiseasegeneticsAPOE4long-read sequencingdrug developmentgenetic risk factorsAfrican American ancestrygenome sequencingtargeted genomics
Research Aims
5AIM 01Understand how genetic variants near the APOE4 gene influence Alzheimer's risk.
AIM 02Identify novel drug targets for Alzheimer's disease.
AIM 03Investigate the differences in genetic risk factors between African American and European American populations.
AIM 04Utilize long-read sequencing to detect large genetic mutations associated with Alzheimer's disease.
AIM 05Analyze protein structure and function related to gene variants.
Skills the Lab Values
long-read sequencingDNA extractionRNA sequencingfibroblast culturewhite blood cell isolationgenetic variant analysisbioinformaticsdata interpretationliterature review
Output against the department
Publications276top 25% of dept.171st of 671
this lab
most publishedleast published
Citations51ktop 7% of dept.44th of 671
this lab
most citedleast cited
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