Harvard University · GeneticsFabkin Research Laboratory
Gokhan S Hotamisligil · Cambridge, Massachusetts
Research Focus
Dr. Gokhan Hotamisligil's research focuses on understanding the role of a newly identified hormone complex named Fabkin in the context of atherosclerosis, a leading cause of cardiovascular diseases. The lab investigates how this complex influences lipid metabolism and inflammation, aiming to discover novel therapeutic strategies to improve current treatments for these conditions. Through animal studies and cellular experiments, the team seeks to unravel the mechanisms behind dyslipidemia and its contribution to heart disease.
atherosclerosislipid metabolisminflammationFabkindyslipidemiahormone signalingpurinergic signalingtherapeutic targetscardio-metabolic diseases
Research Aims
3AIM 01Investigate the effects of Fabkin deficiency on dyslipidemia and atherosclerosis using genetic mouse models.
AIM 02Elucidate the role of Fabkin in hepatic lipid metabolism, particularly de novo lipogenesis and VLDL secretion.
AIM 03Examine Fabkin's impact on macrophage responses to cholesterol stress, including inflammation and cell death.
Skills the Lab Values
animal modelscell cultureimmunohistochemistryWestern blottingRNA extractionPCRflow cytometrybiochemical assaysexperimental design
Output against the department
Publications13bottom 2% of dept.255th of 259
this lab
most publishedleast published
Citations5.2kbottom 29% of dept.185th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.