Johns Hopkins University · NeuroscienceNuclear Transport Research Lab
Alyssa Coyne · Baltimore, Maryland
Research Focus
Dr. Alyssa Coyne's lab investigates the molecular mechanisms underlying neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The research focuses on how disruptions in the nuclear pore complex affect cellular functions in neurons and contribute to disease progression. By studying induced pluripotent stem cell-derived neurons and human tissues, they aim to uncover potential therapeutic targets to prevent or mitigate neurodegeneration.
neurodegenerationALSFTDnuclear pore complexESCRT-IIICHMP7cell biologynuclear transportiPSC-derived neurons
Research Aims
4AIM 01Identify the mechanisms facilitating nuclear entry of CHMP7 in neurons
AIM 02Determine the processes involved in the nuclear export of CHMP7
AIM 03Investigate how CHMP7 mediates nuclear pore complex injury
AIM 04Explore the pathogenic cascades initiated by CHMP7 in ALS and FTD
Skills the Lab Values
induced pluripotent stem cell culturebiochemical assayslive cell imagingsuper-resolution microscopyRNA interference (siRNA)protein interaction analysisconfocal imaginggenetic engineeringdata analysis in biological research
Output against the department
Publications57bottom 14% of dept.580th of 671
this lab
most publishedleast published
Citations2.9kbottom 20% of dept.535th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.