University of California-Irvine · PhysiologyThe Immune Nexus Lab
Shivashankar Othy · Irvine, California
Research Focus
Dr. Shivashankar Othy's lab at UC Irvine focuses on understanding how specific immune cells, known as regulatory T cells, operate in the central nervous system during autoimmune diseases like multiple sclerosis. The research aims to uncover how these immune cells can help reduce inflammation and promote tissue repair. By employing advanced imaging techniques, the lab seeks to reveal new details about the interactions within the immune system that could lead to better treatments for autoimmune disorders.
autoimmune diseasesmultiple sclerosisregulatory T cellstwo-photon microscopyCNStissue repairneuroinflammationimmune regulationtherapeutic strategiesEAE model
Research Aims
5AIM 01Investigate how regulatory T cells interact within the central nervous system.
AIM 02Determine the mechanisms that allow Treg cells to limit neuroinflammation.
AIM 03Identify specific local cues affecting Treg cell behavior in tissue niches.
AIM 04Explore therapeutic targets to enhance Treg cell function in the immune response.
AIM 05Advance understanding of Treg cell roles in autoimmunity and tissue repair.
Skills the Lab Values
two-photon microscopycell culturemouse models (EAE)Ca2+ signaling assaysimmunofluorescenceflow cytometrymolecular biology techniquesimage analysisin vivo imagingexperimental design
Output against the department
Publications49bottom 7% of dept.266th of 286
this lab
most publishedleast published
Citations1.9kbottom 11% of dept.255th of 286
this lab
most citedleast cited
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