Princeton University · EngineeringThe Lung Development Lab
Celeste M Nelson · Princeton, New Jersey
Research Focus
Dr. Celeste M. Nelson's lab at Princeton University is focused on understanding lung development, specifically the processes that prepare the lungs for breathing after birth. The lab investigates how certain pathways help thin the lung's supportive tissue, which is crucial for the formation of air sacs that facilitate gas exchange. By using advanced imaging, genetic techniques, and mechanical assessments, the lab aims to uncover the cellular and molecular mechanisms involved in these processes, especially in cases of prematurity that can affect lung function later in life.
lung developmentmesenchymecell polaritysacculationprematuritybiomechanicsmolecular signaling
Research Aims
3AIM 01Identify how Vangl affects the mechanical properties of mesenchymal tissues during lung development.
AIM 02Discover molecular components of the mesenchyme-specific planar cell polarity pathway influenced by Vangl.
AIM 03Examine the role of Wnt5a in mediating Vangl's effects on mesenchymal thinning and extracellular matrix remodeling.
Skills the Lab Values
live imaging techniquestissue-specific knockout mouse modelssuper-resolution microscopyatomic force microscopyfluorescent in situ hybridizationsingle-cell transcriptomicsproteomicsmechanical testing of tissuescell culture techniques
Output against the department
Publications448top 15% of dept.41st of 278
this lab
most publishedleast published
Citations20ktop 19% of dept.52nd of 278
this lab
most citedleast cited
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