University of Pittsburgh-Pittsburgh Campus · Biomedical EngineeringThe HPV ImmunoLab
Jing Hong Wang · Pittsburgh, Pennsylvania
Research Focus
Dr. Jing Hong Wang's lab at the University of Pittsburgh focuses on understanding how head and neck cancer that is associated with human papillomavirus (HPV) responds to immunotherapy. The team studies the immune system's reaction to HPV antigens and how different T cell receptors impact treatment effectiveness. Their research aims to improve therapies for patients with HPV-positive cancers by exploring the mechanisms driving treatment resistance and response.
HPVhead and neck cancerimmunotherapyT cell receptorstumor-infiltrating lymphocytes
Research Aims
5AIM 01Investigate the role of anti-HPV immune responses in the effectiveness of immune checkpoint inhibitors.
AIM 02Characterize the breadth and depth of T cell receptor responses to HPV antigens in head and neck cancer.
AIM 03Determine the mechanistic link between T cell receptor clonotypes and treatment responses in HPV-positive head and neck squamous cell carcinoma.
AIM 04Utilize clinical trial samples to explore the correlation of T cell transcriptomics with treatment efficacy.
AIM 05Develop new therapeutic approaches targeting HPV-positive tumors based on immune response data.
Skills the Lab Values
cell cultureimmunohistochemistrymouse modelsflow cytometryRNA sequencing