Icahn School of Medicine at Mount Sinai · GeneticsNiemann-Pick Disease Research Unit
Edward H. Schuchman · New York, New York
Research Focus
Dr. Edward H. Schuchman's lab focuses on understanding and developing treatments for two rare neurological disorders known as Niemann-Pick diseases, Types A/B and C. These conditions involve the accumulation of harmful substances in cells, leading to severe neurological impacts with no current effective treatments. The lab is exploring the use of endocannabinoid-based therapies as a potential solution, aiming to improve patient outcomes and deepen our understanding of related neural diseases.
Niemann-Pick DiseaseendocannabinoidsCNS disordersgenetic diseasestherapeutic development
Research Aims
3AIM 01Characterize the protective molecular mechanisms of FAAH inhibition in Niemann-Pick disease A/B
AIM 02Investigate the endocannabinoid system's role in Niemann-Pick disease C
AIM 03Utilize multi-omic approaches to compare pathways in Niemann-Pick diseases A/B and C to better understand their molecular changes.
Skills the Lab Values
cell cultureanimal modelsmolecular biology techniquesgene expression analysissystem biologydata analysisproteomicsRNA sequencing
Output against the department
Publications516top 13% of dept.34th of 259
this lab
most publishedleast published
Citations21ktop 28% of dept.72nd of 259
this lab
most citedleast cited
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