Johns Hopkins University · BiochemistryTRIM37 Innovations Lab
Sergi Regot · Baltimore, Maryland
Research Focus
Dr. Sergi Regot's lab at Johns Hopkins University focuses on cancer research, particularly how certain genetic changes within tumors can affect cancer growth and response to treatment. They are exploring a protein called TRIM37 and its role in making some cancer cells more vulnerable to specific therapies that target a protein involved in cell division. The aim is to find new ways to treat aggressive cancers, such as breast cancer and neuroblastoma, that show genetic alterations.
TRIM37tumorigenesisPLK4cancer therapysynthetic lethalitybreast cancerneuroblastomagenomic instability
Research Aims
3AIM 01Define how TRIM37 overexpression increases vulnerability to PLK4 inhibitors.
AIM 02Investigate if PPM1D overexpression influences genomic instability in cancer models.
AIM 03Test the therapeutic effectiveness of PLK4 inhibitors in human cancer organoids with TRIM37 amplification.
Skills the Lab Values
cell culturecancer organoid modelsgene amplification techniquesdrug sensitivity assaysmitotic error analysisgenomic testingbiochemical assaysPCRWestern blottingflow cytometry
Output against the department
Publications40bottom 4% of dept.383rd of 402
this lab
most publishedleast published
Citations3.6kbottom 18% of dept.331st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.