University of Pennsylvania · BiologyEpigenetic Metabolism Lab
Shelley L Berger · Philadelphia, Pennsylvania
Research Focus
Dr. Shelley L. Berger's lab at the University of Pennsylvania focuses on understanding the link between epigenetics and metabolism in cancer. The lab studies how changes in these pathways can affect gene expression and contribute to cancer development. They aim to develop new therapeutic strategies by investigating the role of specific enzymes and regulatory elements in these processes.
cancerepigeneticsmetabolismgene expressionchromatinp53transcription factorsenhancersnuclear metabolic pathwaystumor suppressors
Research Aims
5AIM 01Investigate the interaction between nuclear epigenetic and metabolic pathways in cancer.
AIM 02Uncover mechanisms by which p53 regulates gene expression through chromatin and nuclear speckles.
AIM 03Explore novel roles of metabolic enzymes in epigenetic regulation.
AIM 04Identify new therapeutic targets within the metabolic-epigenetic axis.
AIM 05Develop inhibitors targeting specific metabolic enzymes linked to cancer.
Skills the Lab Values
cell culturemouse modelsRNA sequencingprotein assayschromatin immunoprecipitationWestern blottinggenomicsproteomicsdata analysismetabolic pathway analysis
Output against the department
Publications499top 8% of dept.84th of 1,033
this lab
most publishedleast published
Citations59ktop 3% of dept.35th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.