University of Nebraska Medical Center · BiologyT Cell and Infection Dynamics Lab
Tammy L Kielian · Omaha, Nebraska
Research Focus
Dr. Tammy Kielian's lab focuses on understanding how immune cells, particularly T cells, interact with the bacterium Staphylococcus aureus during infections that can occur after brain surgeries like craniotomies. The lab investigates how these immune responses can both help and hinder the body's ability to eliminate biofilms formed by this bacteria, aiming to improve treatments for infections that can lead to serious complications.
T cell biologyStaphylococcus aureusbrain infectionbiofilmimmune responsecraniotomyantimicrobial strategiesinnate immunityinfection mechanisms
Research Aims
3AIM 01Identify the role of specific T cell subtypes in controlling Staphylococcus aureus during brain infections.
AIM 02Explore the mechanisms of crosstalk between T cells and innate immune cells that affect biofilm persistence.
AIM 03Investigate the virulence factors of Staphylococcus aureus that contribute to its resistance against T cell responses.
Skills the Lab Values
cell culturemouse modelsRNA sequencingflow cytometryWestern blottransfectionsurvivorship assaysimmunohistochemistrybiological data analysis
Output against the department
Publications214top 30% of dept.308th of 1,033
this lab
most publishedleast published
Citations11ktop 33% of dept.336th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.