University of Michigan-Ann Arbor · PharmacologyThe GSTO1 Initiative
Nouri Neamati · Ann Arbor, Michigan
Research Focus
Dr. Nouri Neamati's lab focuses on developing new drugs targeting a specific protein called GSTO1, which plays a crucial role in colorectal cancer and drug resistance. They use advanced techniques like gene editing and bioinformatics to understand how GSTO1 contributes to cancer progression and to find ways to inhibit it effectively. The lab's research aims not only to improve cancer therapies but also to provide insights into the immune response against tumors, making it relevant for advancing cancer treatment options.
GSTO1colorectal cancerdrug resistancecancer therapeuticsimmune responsePROTACCRISPR/Cas9bioinformaticsproteomics
Research Aims
3AIM 01Elucidate the functions of GSTO1 in enhancing immune response and reducing tumor cell viability.
AIM 02Optimize GSTO1 degraders based on co-crystal structures to select a clinical candidate.
AIM 03Assess in vivo efficacy of promising novel GSTO1 degraders in colorectal cancer models as single agents and in combination.
Skills the Lab Values
CRISPR/Cas9small-molecule drug designin vitro cell culture3D spheroid assaysproteomicsRNA sequencingsiRNA and shRNA techniquesbioinformatics analysisdrug efficacy testing
Output against the department
Publications357top 19% of dept.89th of 462
this lab
most publishedleast published
Citations15ktop 25% of dept.115th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.