University of Illinois Urbana-Champaign · BiologyFlaws Reproductive Lab
Jodi A. Flaws · Champaign, Illinois
Research Focus
Dr. Jodi A. Flaws' lab at the University of Illinois focuses on the impact of environmental chemicals, specifically phthalates and endocrine disrupting chemicals (EDCs), on female reproductive health. The lab investigates how these chemicals contribute to early reproductive aging, which can lead to issues like infertility and other health complications in midlife women. By using advanced techniques to understand the mechanisms behind EDC-induced ovarian damage, the lab aims to identify potential treatments and preventive strategies.
phthalatesendocrine disrupting chemicalsfemale reproductive healthreproductive agingovarian damage
Research Aims
5AIM 01Investigate how phthalate exposure affects reproductive aging in female mice.
AIM 02Identify the inflammatory mechanisms induced by EDCs in the ovary.
AIM 03Study the multigenerational effects of EDCs on female reproductive health.
AIM 04Explore the role of the aryl hydrocarbon receptor in reproductive aging.
AIM 05Develop potential treatments for phthalate-induced reproductive dysfunction.
Skills the Lab Values
cell culturesingle cell RNA sequencingCRISPR3D ovarian follicle culturespatial transcriptomicshigh-resolution LC-MS/MSbiomarker analysisDNA methylation analysisproteomicsstatistical modeling
Output against the department
Publications491top 8% of dept.87th of 1,033
this lab
most publishedleast published
Citations25ktop 16% of dept.165th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.