Columbia University in the City of New York · BiochemistryThe Conformational Dynamics Lab
Arthur G Palmer · New York, New York
Research Focus
Arthur G. Palmer's lab focuses on understanding how the shapes of proteins and their movements influence their functions in biological processes. They study conformational changes in proteins—like how they fold or interact with other molecules—using advanced techniques such as NMR spectroscopy and molecular dynamics simulations. Their research has implications for various diseases and can aid in the design of new therapeutic agents.
protein dynamicsNMR spectroscopyenzyme catalysismolecular recognitiontranscription factorsprotein-protein interactionsconformational changesDNA recognitioncadherin dimerizationbiophysical methods
Research Aims
5AIM 01Investigate the role of conformational changes in enzyme catalysis.
AIM 02Explore structural dynamics in protein-protein interactions.
AIM 03Determine the conformational states of transcription factors during DNA binding.
AIM 04Assess the effects of protein dynamics on molecular recognition.
AIM 05Develop new methods for studying macromolecular dynamics.
Skills the Lab Values
NMR spectroscopymolecular dynamics simulationsprotein purificationgel electrophoresiskinetic assayscell culture techniquesWestern blottingDNA manipulationspectroscopic data analysiscomputational modeling
Output against the department
Publications250top 30% of dept.119th of 402
this lab
most publishedleast published
Citations17ktop 27% of dept.107th of 402
this lab
most citedleast cited
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