University of New Hampshire-Main Campus · BiochemistryDehydration Tolerance Research Lab
Matthew David Macmanes · Durham, New Hampshire
Research Focus
Professor Matthew David Macmanes at the University of New Hampshire studies why some rodents can survive with very little water. His lab focuses on understanding the biological and genetic factors that allow these animals to tolerate dehydration. The goal of the research is to apply this knowledge to improve human health, particularly for vulnerable populations who suffer from dehydration. By learning how these rodents manage water loss and preserve organ function, the lab aims to find new ways to help humans cope with dehydration-related health risks.
dehydration tolerancerodent physiologybiochemical pathwaysgenomic mechanismsorgan preservation
Research Aims
5AIM 01Investigate the physiological mechanisms of dehydration tolerance in rodents.
AIM 02Identify genomic factors that contribute to water conservation in these animals.
AIM 03Explore the role of the RAAS system in organ function during dehydration.
AIM 04Evaluate the impact of reduced metabolism and activity on dehydration survival.
AIM 05Develop strategies to apply findings to human health in dehydration mitigation.
Skills the Lab Values
animal modelsgenomicsbiochemical assaysmetabolic measurementsmolecular biology techniques
Output against the department
Publications138bottom 39% of dept.244th of 402
this lab
most publishedleast published
Citations12ktop 41% of dept.165th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.