Washington University in St Louis · BiologyMurphy Lab
Kenneth M Murphy · Saint Louis, Missouri
Research Focus
Dr. Kenneth M. Murphy's lab at Washington University explores how specific dendritic cells, called cDC1, help the immune system recognize and respond to infections and tumors. The lab focuses on the role of a protein named WDFY4 in both Treg (regulatory T cell) development and antigen presentation, essential for activating the immune response. Their research aims to uncover new treatment pathways for autoimmunity and cancer immunotherapy.
Treg developmentcross-presentationdendritic cellscDC1WDFY4immune tolerancecancer immunotherapyautoimmunity
Research Aims
3AIM 01Investigate the role of WDFY4 in Treg receptor repertoire and function
AIM 02Explore how cDC1 and cDC2 differ in antigen presentation
AIM 03Identify proteins that interact with WDFY4 to understand its function in immune responses
Skills the Lab Values
CRISPR/Cas9cell culturemouse modelsimmunohistochemistryflow cytometryMHC class I and II analysisprotein-protein interaction studiesWestern blotin vivo imaginggenetic manipulation
Output against the department
Publications467top 9% of dept.92nd of 1,033
this lab
most publishedleast published
Citations73ktop 2% of dept.19th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.