University of Maryland, Baltimore · PharmacologyCalcium Channel Research Laboratory
Ivy E Dick · Baltimore, Maryland
Research Focus
Dr. Ivy E. Dick's lab focuses on understanding how certain calcium channel mutations contribute to neurodevelopmental disorders, such as autism spectrum disorder. By studying mutated calcium channels and their effects on neuronal function, the lab aims to identify new treatment strategies, particularly for conditions like Timothy syndrome. The research combines advanced cellular models and innovative genetic techniques to explore how calcium signaling influences brain function and disease pathology.
Calcium ChannelsNeurodevelopmental DisordersTimothy SyndromeAutism Spectrum DisorderCa2+ Signaling
Research Aims
5AIM 01Investigate the role of CaV1.2 calcium channel mutations in neurodevelopmental disorders.
AIM 02Explore the impact of altered calcium signaling on neuronal excitability.
AIM 03Develop new treatment options for Timothy syndrome using antisense oligonucleotides.
AIM 04Analyze the relationships between channel splicing variations and disease outcomes.
AIM 05Utilize iPSC-derived neurons to study disease mechanisms at a cellular level.
Skills the Lab Values
Induced Pluripotent Stem Cell (iPSC) TechnologyPatch Clamp ElectrophysiologyCa2+ ImagingSingle-Cell RNA SequencingTransgenic Mouse ModelsCRISPR Gene EditingQuantitative Molecular Biology Techniques
Output against the department
Publications95bottom 23% of dept.355th of 462
this lab
most publishedleast published
Citations2.0kbottom 14% of dept.398th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.