University of Michigan-Ann Arbor · PharmacologyScott Lab
Emily E Scott · Ann Arbor, Michigan
Research Focus
Dr. Emily E. Scott's lab focuses on understanding human cytochrome P450 enzymes, which play a crucial role in drug metabolism and are also potential targets for treating various diseases. By using advanced structural and biochemical techniques, the lab aims to uncover the structure and function of these enzymes, providing insights that could lead to better drug design and therapies for both common and rare diseases. The research not only seeks to improve drug therapy but also to identify how mutations in these enzymes can lead to health issues.
Cytochrome P450Drug metabolismDisease-related enzymesX-ray crystallographyInhibitionRare diseasesHuman healthPharmacologyDrug designBiochemical techniques
Research Aims
5AIM 01Determine the structure of poorly-characterized human P450 enzymes
AIM 02Identify specific ligands that interact with P450 enzymes
AIM 03Evaluate the impact of clinical mutations on P450 function
AIM 04Investigate the interactions between P450 enzymes, lipids, and other proteins
AIM 05Advance drug design by understanding P450 enzyme mechanisms
Skills the Lab Values
X-ray crystallographyProtein purificationRecombinant DNA technologyLigand binding assaysSubstrate metabolism studiesEnzyme kineticsMolecular modelingProtein-ligand interaction analysisBiochemical assay development
Output against the department
Publications172bottom 47% of dept.243rd of 462
this lab
most publishedleast published
Citations4.7kbottom 35% of dept.301st of 462
this lab
most citedleast cited
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