Brown University · BiochemistryAccornero Lab
Federica Accornero · Providence, Rhode Island
Research Focus
Dr. Federica Accornero's lab at Brown University focuses on uncovering the molecular mechanisms that regulate aging and heart function through post-transcriptional modifications of RNA. The lab explores how specific RNA methylation processes, particularly involving the enzyme METTL3, influence gene expression related to aging and cardiac health. By studying these processes, the lab aims to identify potential therapeutic targets for age-related diseases and heart failure.
mRNA methylationagingcardiac hypertrophyMETTL3post-transcriptional regulationheart failuregene expressionsarcopeniatherapeutic development
Research Aims
4AIM 01Investigate how METTL3-mediated m6A methylation affects mRNA translation in aging.
AIM 02Examine the therapeutic potential of enhancing m6A content to combat muscle aging.
AIM 03Understand the role of METTL3 in regulating heart function during stress.
AIM 04Identify mechanisms that govern METTL3 activity and specificity in cardiac remodeling.
Skills the Lab Values
mRNA extractionPCRanimal modelsWestern blotRNA sequencinggene editingcell culturetranscriptional assaysmouse models
Output against the department
Publications83bottom 17% of dept.332nd of 402
this lab
most publishedleast published
Citations3.0kbottom 14% of dept.346th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.