Drexel University · PhysicsSickle Cell Research Laboratory
Frank A Ferrone · Philadelphia, Pennsylvania
Research Focus
Dr. Frank Ferrone's lab at Drexel University focuses on understanding sickle cell disease and improving treatments for it. The research aims to uncover how fetal hemoglobin can reduce the harmful effects of sickle hemoglobin, helping to optimize existing gene therapies and discover new drug treatments. By investigating the basic mechanisms of hemoglobin behavior, the lab contributes to better therapeutic strategies for this widespread condition.
sickle cell diseasegene therapyfetal hemoglobindrug discoveryanti-sickling compoundspolymerizationcell biologyhigh-throughput screening
Research Aims
3AIM 01Develop a mechanistic understanding of how fetal hemoglobin modulates sickle hemoglobin polymerization.
AIM 02Reconcile in vitro and in-cell polymerization of hemoglobins.
AIM 03Probe the mechanisms of action for newly identified anti-sickling compounds.
Skills the Lab Values
cell culturehigh-throughput screeningin vitro experimentationkinetics measurementfluorescence microscopyprotein binding assaysdata analysis with Pythonmolecular modelingquantitative PCR
Output against the department
Publications131bottom 18% of dept.18th of 22
this lab
most publishedleast published
Citations4.3kbottom 27% of dept.16th of 22
this lab
most citedleast cited
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