Case Western Reserve University · BiologyNeuroProtection Lab
David E Kang · Cleveland, Ohio
Research Focus
Dr. David E. Kang's lab at Case Western Reserve University focuses on understanding the mechanisms behind neurodegenerative diseases such as Alzheimer's, ALS, and frontotemporal lobar degeneration. The lab studies the role of specific proteins, including TDP-43 and Nrf2, in regulating cellular responses to stress and their impacts on neurodegeneration. By utilizing animal models and advanced biochemical techniques, the lab aims to find potential therapeutic targets to mitigate the detrimental effects caused by these proteins.
TDP-43Alzheimer's DiseaseNrf2neurodegenerationtauopathiesdeubiquitinationoxidative stressER stressbehavioral studiesproteomics
Research Aims
5AIM 01Investigate the role of USP19 in TDP-43 pathology and its impact on neurodegeneration.
AIM 02Examine how the SSH1-Nrf2 nexus influences the balance between neuronal protection and degeneration.
AIM 03Determine the mechanisms behind TDP-43 deubiquitination and its consequences in neurotoxicity.
AIM 04Identify potential therapeutic approaches targeting USP19 to alleviate neurodegenerative symptoms.
AIM 05Analyze the regulatory interactions between oxidative stress responses and neurodegenerative processes.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysRNA sequencingimmunohistochemistryproteomicsviral transfectionelectrophysiologyimaging techniquesbiostatistics
Output against the department
Publications104bottom 36% of dept.658th of 1,033
this lab
most publishedleast published
Citations6.8kbottom 47% of dept.543rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.