Vanderbilt University · BiologyCerebellar Development and Disorders Lab
Chin Chiang · Nashville, Tennessee
Research Focus
Dr. Chin Chiang's research lab at Vanderbilt University focuses on understanding how granule cells in the cerebellum develop and how their improper formation can lead to conditions like cerebellar hypoplasia, which is particularly common in premature infants. The lab investigates the genetic and epigenetic factors that control the progression and differentiation of granule cell precursors, linking basic developmental biology to potential health implications in neurological disorders.
cerebellumgranule cellscell differentiationepigeneticsneurodevelopmentcerebellar hypoplasiatranscription factorscell cycle regulationpremature infantsneurodevelopmental disorders
Research Aims
5AIM 01Investigate the role of Sin3A in granule cell lineage development.
AIM 02Determine how Insm1 influences granule cell precursor differentiation.
AIM 03Elucidate the autoregulatory feedback mechanisms involved in granule cell development.
AIM 04Explore how epigenetic factors impact the expression of critical transcription factors.
AIM 05Clarify the connection between transcriptional regulation and cell cycle progression in granule cells.
Skills the Lab Values
PCRcell culturegene expression analysisWestern blotepigenetic modification techniquesin vitro cell differentiation assayselectrophoretic mobility shift assay (EMSA)histone modification assayszinc-finger protein analysisdata analysis in development biology
Output against the department
Publications77bottom 22% of dept.800th of 1,033
this lab
most publishedleast published
Citations12ktop 32% of dept.326th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.