University of Kentucky · PharmacologyNorris Lab
Christopher Mark Norris · Lexington, Kentucky
Research Focus
Dr. Christopher Mark Norris' lab at the University of Kentucky focuses on understanding the role of reactive astrocytes in Alzheimer's disease and related dementias. By utilizing advanced mouse models and innovative cell-specific targeting techniques, they investigate how different aspects of astrocyte function contribute to brain pathology in dementia. The lab aims to bridge preclinical findings with human data to improve therapeutic strategies for these diseases.
Alzheimer's Diseasedementiareactive astrocytesastrocyte targetingbrain pathologyneurodegenerationbiomarkersmouse modelsneurosciencecell signaling
Research Aims
4AIM 01Investigate how reactive astrocyte phenotypes contribute to Alzheimer's disease pathology.
AIM 02Assess cerebrovascular dysfunction and metabolic changes using advanced imaging techniques.
AIM 03Validate preclinical findings through analysis of human biomarker data.
AIM 04Explore the therapeutic potential of targeting astrocytic functions in dementia.
Skills the Lab Values
animal modelstissue processingtwo-photon microscopymagnetic resonance imaging (MRI)microelectrode array electrophysiologybiochemical assaysdata managementbiostatisticscell culturegene expression analysis
Output against the department
Publications180bottom 49% of dept.233rd of 462
this lab
most publishedleast published
Citations7.5ktop 48% of dept.222nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.